Search results for "molecular biomarkers"

LncRNA H19, HOTAIR AND MALAT1 AS MOLECULAR BIOMARKERS IN GIST

Molecular biomarkers in glaucoma

2013

The seventh annual ARVO/Pfizer Ophthalmic Research Institute conference was held Friday and Saturday, April 29 and 30, 2011, at the Fort Lauderdale Hyatt Regency Pier 66, Fort Lauderdale, Florida. The conference, funded by The ARVO Foundation for Eye Research through a grant from Pfizer Ophthalmics, provided an opportunity to gather experts from within and outside ophthalmology to determine the state of knowledge pertaining to molecular biomarkers associated with glaucoma, as well as the methods to identify and validate them to predict (a) those who would be susceptible to development of glaucoma; (b) markers that will enable prediction of glaucoma progression; and (c) markers that will pre…

Prognostic and predictive biomarkers for targeted therapy in NSCLC: For whom the bell tolls?

2015

Introduction: The discovery of molecular biomarkers and the advent of targeted therapies have led to a radical change in the treatment of several tumors, including NSCLC. In the last few years, the number of molecular biomarkers has rapidly increased, and a growing interest has been recently focused on their potential prognostic and predictive value in clinical settings. Areas covered: This review describes all the molecular biomarkers with prognostic and predictive value in NSCLC, including both clinically approved biomarkers, and emerging biomarkers under investigation in clinical trials. Liquid biopsy and applications of circulating biomarkers are also described. Expert opinion: The onco…

Liquid Biopsy in Gynecological Cancers

2017

Gynecological cancers originate in woman’s reproductive organs, including ovarian, uterine or endometrial, cervical, vulvar, and vaginal cancers. These tumors are a leading health problem for women accounting for more than 20% of new cases and cancer-related deaths worldwide. Gynecological cancers are characterized by an aggressive biological behavior with a clinical presentation often in advanced stage of disease. This chapter will focus on the potential role of the novel molecular approaches based on liquid biopsy in detecting occult disease, monitoring the progression and identifying treatment-resistance in gynecological cancer patients. The ability to detect circulating tumor DNA (ct-DN…

Chemical and biochemical responses to sub−lethal doses of mercury and cadmium in gilthead seabream (Sparus aurata)

2022

Specimens of Sparus aurata were exposed to sub-lethal concentrations of Hg and Cd for 25 days and the levels of both metals were investigated in organs and tissues. Bioaccumulation of Hg decreased as follow: gills > kidney > liver > skin > muscle, while the order of Cd bioaccumulation was: liver > kidney > gills > skin > muscle. Immediately after exposure, both metals showed the highest bioaccumulation in gills and skin indicating that these organs are reliable targets for biomonitoring studies after short term exposure. Metals introduction caused a significant time-dependent concentrations increase in kidney and liver, while in the muscle a significant in-crease of …

Environmental responses of past and recent agropastoral activities on south Greenlandic ecosystems through molecular biomarkers

2016

Paleoenvironmental studies previously performed on Lake Igaliku revealed two agropastoral phases in south Greenland: the Norse settlement from AD 986 to ca. AD 1450 and the recent installation of sheep farmers, since the 1920s. To improve the knowledge of the timing and magnitude of the Greenlandic agropastoral activities, a lipid inventory was realized and compared with biological and geochemical data. During the 12th century, a major increase in deoxycholic acid (DOC) and coprophilous fungal spores revealed a maximum of herbivores. Synchronously, a minimum of the n-C29/ n-C31 alkane ratio and tree and shrub pollen and a maximum of triterpenyl acetates showed a reduction in the tree and s…

Cardiac magnetic resonance-derived fibrosis, strain and molecular biomarkers of fibrosis in hypertensive heart disease

2020

Aims Myocardial fibrosis is a relevant component of hypertensive heart disease (HHD). Novel cardiovascular magnetic resonance (CMR) imaging techniques have shown potential in quantification of diffuse cardiac fibrosis, with T1 mapping, and estimating preclinical cardiac dysfunction, with strain analysis. Molecular biomarkers of fibrosis have been related with clinical outcomes and histologically proven myocardial fibrosis. The relationship between these CMR-imaging techniques and circulating biomarkers is not fully understood. Methods and results CMR was performed on a 3T scanner in 36 individuals with HHD. Extracellular volume fraction (ECV) and the partition coefficient were assessed usin…

LncRNA H19, HOTAIR and MALAT1 as prognostic molecular biomarkers in GIST

2017

Molecular Biomarkers of Aging

2012

Sergio Davinelli1, Sonya Vasto2, Calogero Caruso2, Davide Zella3 and Giovanni Scapagnini1 1Department of Health Sciences, University of Molise, Campobasso, 2Department of Pathobiology and Biomedical Methodologies, Immunosenescence Unit, University of Palermo, Palermo, 3Department of Biochemistry and Molecular Biology, Institute of Human Virology-School of Medicine, University of Maryland, Baltimore, MD, 1,2Italy 3USA